Substituted anilide ligands for the thyroid receptor

US7342127B2 · kind B2 · utility

Assignees

• Bristol-Myers Squibb Company · US
• Karo Bio AB · SE

Inventors

• William N. Washburn · Titusville, US
• Wei Meng · Pennington, US
• Denis E. Ryono · Princeton, US
• Bruce A. Ellsworth · Princeton, US
• Thomas Ericsson
• Mahmoud Rahimi-Ghadim · Stockholm, SE
• Neeraj Garg · Tumba, SE
• Johan Malm · Älta, SE

Key dates

• Filing date: Jan 23, 2004
• Grant date: Mar 11, 2008
• Expiry date: Dec 3, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C233/25
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel thyroid receptor ligands are provided having the general formula Iwherein In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolic dysfunction or which are dependent upon the expression of a T3 regulated gene, wherein a compound as described above is administered in a therapeutically effective amount.