Process for the synthesis of Losartan potassium

US7345071B2 · kind B2 · utility

Assignee

• IPCA LABORATORIES LIMITED · IN

Inventors

• Ashok Kumar · Jamkhed, IN
• Rajesh Kumar Singh · Ludhiana, IN
• Nalinakshya Balaram Panda · Vasai, IN
• Abhay Atmaram Upare · Mumbai, IN
• Manmohan Nimbalkar · Mumbai, IN
• Satish Rajanikant Soudagar · Mumbai, IN
• Ashvini Saxena · Bengaluru, IN

Key dates

• Filing date: Aug 5, 2004
• Grant date: Mar 18, 2008
• Expiry date: Aug 19, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Improved processes using primary, secondary and tertiary alcohols and with safer mode of introduction of the reagent and reaction conditions are described. Further, the process of manufacture of Losartan potassium by use of alkali metal salt such as Potassium carbonate is disclosed. A process for preparation of the polymorphic Form I of Losartan potassium is also disclosed herein.