Process for separating and deprotecting oligonucleotides
US7345163B2 · kind B2 · utility
0Cited by
15References
18Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 28, 2002 |
| Grant date | Mar 18, 2008 |
| Priority date | — |
| Expiry date | Jul 13, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods for deprotecting and derivatizing oligonucleotides that are non-covalently bound to a solid support are described. The methods include providing a plurality of oligonucleotides linked to one or more hydrophobic separation functions, wherein the plurality includes protected oligonucleotides, precipitating the plurality of oligonucleotides on a hydrophobic solid support using an organic solvent to produce non-covalently immobilized oligonucleotides, and deprotecting the immobilized oligonucleotides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.