Isethionate salt of a selective CKD4 inhibitor

US7345171B2 · kind B2 · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Vladimar Beylin · Ann Arbor, US
• Anthony C. Blackburn · San Diego, US
• David Erdman · Neunburg vorm Wald, DE
• Peter L. Toogood · Ann Arbor, US

Key dates

• Filing date: Jul 6, 2004
• Grant date: Mar 18, 2008
• Expiry date: Nov 29, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are polymorphs of the isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one,which is a selective cyclin-dependent kinase 4 (CDK4) inhibitor useful for treating inflammation and cell proliferative diseases such as cancer and restenosis.