Process for preparing benzhydrylthioacetamide
US7345188B2 · kind B2 · utility
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33Claims
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Key dates
| Filing date | Oct 22, 2004 |
| Grant date | Mar 18, 2008 |
| Priority date | — |
| Expiry date | Jun 28, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C315/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to an improved process for preparing modafinil wherein benzhydrylthioacetate is prepared in high yield and purity by the reaction of a haloacetate with the reaction product of thiourea and benzhydrol. The reaction employing the haloacetate is conducted in a solvent comprising an organic solvent such as methanol having dissolved therein an organic base or an inorganic basic salt such as sodium bicarbonate. The resulting benzhydrylthioacetate can be amidated and then oxidized to provide the pharmaceutical grade modafinil in high yield and purity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.