Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)

US7348346B2 · kind B2 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Irini Akritopoulou-Zanze · Libertyville, US
• Daria Darczak · Chicago, US
• Jurgen Dinges · Wadsworth, US
• Stevan W. Djuric · Libertyville, US
• Ethan Hoff · Racine, US
• Hana Kopecka · Vernon Hills, US
• Jyoti R. Patel · Libertyville, US
• Zhonghua Pei · South San Francisco, US
• Qi Shuai · DeKalb, US
• Kathy Sarris · Mundelein, US
• Hing L. Sham · South San Francisco, US
• Paul E. Wiedeman · Libertyville, US

Key dates

• Filing date: Mar 8, 2005
• Grant date: Mar 25, 2008
• Expiry date: Jun 2, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I),which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.