Patent · US Expired

Adeno-associated vector compositions for expression of Factor VIII

US7351577B2 · kind B2 · utility

13Cited by
43References
2Claims
0Family size

Assignee

Inventors

Key dates

Filing dateAug 1, 2003
Grant dateApr 1, 2008
Priority date—
Expiry dateJun 23, 2024

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2830/85
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

One form of a composition has two types of recombinant adeno-associated virus. The first type encodes a portion of Factor VIII operably linked to an expression control element; and the second type encodes a different portion of Factor VIII operably linked to an expression control element. The first and second nucleotide sequences collectively encode a functional Factor VIII protein. Another form of the composition is a recombinant adeno-associated virus containing a nucleotide sequence encoding functional Factor VIII light or heavy chain operably linked to a tissue-specific promoter.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.