Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof

US7351687B2 · kind B2 · utility

Assignee

• Vicuron Pharmaceuticals Inc. · US

Inventors

• Ameriga Lazzarini · Legnano, IT
• Luciano Gastaldo · Pogliano Milanese, IT
• Gianpaolo Candiani · Gorgonzola, IT
• Ismaela Ciciliato · Busto Arsizio, IT
• Daniele Losi · Rovellasca, IT
• Flavia Marinelli · Milano, IT
• Enrico Selva · Gropello Cairoli, IT
• Franco Parenti · Lainate, IT

Key dates

• Filing date: Jan 26, 2005
• Grant date: Apr 1, 2008
• Expiry date: Jan 26, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/01
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation of Microbispora sp. ATCC PTA-5024, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes. Antibiotic 107891, which is a complex comprising two Factors, denominated Factors A1 and A2, has a peptide structure containing lanthionine and methyllanthionine as constituents which are typical characteristics of the antibiotics of the lantibiotics group. Antibiotic 107891 and its Factors A1 and A2 show a good antibacterial activity against Gram-positive bacteria including methicillin resistant and vancomycin resistant strains, and is active also against some Gram-negative bacteria such as M. catharralis, Neisseria species and H. influenzae and Mycobacteria.