Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds

US7351719B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Dirk Stenkamp · Biberach, DE
• Stephan Georg Mueller · Warthausen, DE
• Gerald Juergen Roth · Biberach, DE
• Philipp Lustenberger · Warthausen, DE
• Klaus Rudolf · Warthausen, DE
• Thorsten Lehmann-Lintz · Ochsenhausen, DE
• Kirsten Arndt · Biberach, DE
• Ralf Lotz · Schemmerhofen, DE
• Martin Lenter · Ulm, DE
• Heike-Andrea Wieland · Biberach, DE

Key dates

• Filing date: Oct 31, 2003
• Grant date: Apr 1, 2008
• Expiry date: Dec 4, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to amide compounds of general formula Iwherein the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one amide according to the invention. In view of the MCH receptor-antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.