Liver-specific gene expression cassettes, and methods of use
US7351813B2 · kind B2 · utility
29Cited by
2References
8Claims
0Family size
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Key dates
| Filing date | Jun 18, 2001 |
| Grant date | Apr 1, 2008 |
| Priority date | — |
| Expiry date | Dec 12, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/85
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In one aspect, the present invention provides nucleic acid expression cassettes that are predominantly expressed in the mammalian liver. The present invention also provides vectors comprising a nucleic acid expression cassette that is predominantly expressed in the mammalian liver. The present invention also provides methods of ameliorating the symptoms of a disease, the methods including the steps of introducing into the liver of a mammalian subject a vector comprising a nucleic acid expression cassette that encodes a polypeptide, and expressing a therapeutic amount of the polypeptide in the liver.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.