Preparation process

US7351823B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Mathias Berwe · Sprockhövel, DE
• Christian Thomas · Wuppertal, DE
• Joachim Rehse · Leichlingen, DE
• Dirk Grotjohann · Leverkusen, DE

Key dates

• Filing date: Jan 10, 2005
• Grant date: Apr 1, 2008
• Expiry date: Jun 29, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for preparing 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide starting from 2-[(2S)-2-oxiranylmethyl]-1H-isoindole-1,3(2H)-dione, 4-(4-aminophenyl)-3-morpholinone and 5-chlorothiophene-2-carbonyl chloride.