Aryl acid pyrimidinyl methyl amides, pyridazinyl methyl amides and related compounds
US7351826B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 16, 2004 |
| Grant date | Apr 1, 2008 |
| Priority date | — |
| Expiry date | Sep 4, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides compounds of Formula (I) that bind to GABAA receptors. In the above formula, variables are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals, and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies)
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.