System and method for high sensitivity vibrational imaging with frequency modulation coherent anti-stokes Raman scattering analyses
US7352458B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 15, 2006 |
| Grant date | Apr 1, 2008 |
| Priority date | — |
| Expiry date | Mar 15, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2021/653
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A system is disclosed for detecting a nonlinear coherent field induced in a sample. The system includes optics, a modulation system, and a detector system. The optics are for directing a first electromagnetic field at a first frequency ω1 and a second electromagnetic field at a second frequency ω2 toward a focal volume such that a difference frequency ω1–ω2 is resonant with a vibrational frequency of a sample in the focal volume. The modulation system is for modulating the difference frequency ω1–ω2 such that the difference frequency ω1–ω2 is tuned in and out of the vibrational frequency of the sample of at a modulation frequency. The detector system is for detecting an optical field that is generated through non-linear interaction of ω1 and ω2 and the sample responsive to the modulation frequency.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.