Method of tumor regression with VEGF inhibitors

US7354578B2 · kind B2 · utility

Assignee

• REGENERON PHARMACEUTICALS, INC. · US

Inventors

• Jessica Kandel · New York, US
• Jocelyn Holash · Yonkers, US
• Darrell Yamashiro · Westwood, US
• Jianzhong Huang · Nanhu, CN
• George D. Yancopoulos · Elmhurst, US
• John Rudge · Mahopac, US

Key dates

• Filing date: Jun 4, 2004
• Grant date: Apr 8, 2008
• Expiry date: Oct 20, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of regressing or inhibiting a tumor in a subject by administering an agent capable of blocking, inhibiting, or ameliorating vascular endothelial growth factor (VEGF)-mediated activity to a subject in need thereof such that the tumor is regressed or inhibited. The method of the invention results in a reduction of tumor size and inhibition of tumor metastases. This method is particularly useful for patients suffering from bulky, metastatic cancers.