Functional derivatives of ICAM-1 with altered ability to bind LFA-1 or HRV
US7354588B1 · kind B1 · utility
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4References
16Claims
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Inventors
Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Apr 8, 2008 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.