Method for producing optically active IHOG and monatin
US7354746B1 · kind B1 · utility
16Cited by
0References
22Claims
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Assignee
Inventors
Key dates
| Filing date | Dec 11, 2006 |
| Grant date | Apr 8, 2008 |
| Priority date | — |
| Expiry date | Dec 11, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/88
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and an aldolase which can be used in these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.