Method for rapid generation of mature dendritic cells

US7354909B2 · kind B2 · utility

Assignee

• UNITED STATES OF AMERICA, AS REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES · US

Inventors

• Dennis Klinman · Potomac, US
• Mayda Gursel · Ankara, TR
• Daniela Verthelyi · Potomac, US

Key dates

• Filing date: Aug 13, 2002
• Grant date: Apr 8, 2008
• Expiry date: Aug 5, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2501/056
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel methods for rapidly generating dendritic cells are disclosed herein. The methods include contacting a dendritic cell precursor with a D ODN to generate a mature dendritic cell. In one specific, non/limiting example, the method includes contacting the dendritic cell precursor or the mature dendritic cell with an antigen. The methods are of use both in vitro and in vivo.