Therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia

US7354949B2 · kind B2 · utility

Assignee

• KYOWA HAKKO KOGYO CO., LTD. · JP

Inventors

• Tsuyoshi Yamagata · Oyama, JP
• Kaoru Atsuki · Oyama, JP
• Tetsuji Ohno · Oyama, JP
• Shiro Shirakura · Shizuoka, JP
• Akira Karasawa · Shizuoka, JP

Key dates

• Filing date: Mar 29, 2002
• Grant date: Apr 8, 2008
• Expiry date: Mar 29, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P13/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia comprising, as an active ingredient, a tricyclic compound represented by formula (I):[wherein R1 represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy or halogen;X1-X2-X3 represents CR5═CR6—CR7═CR8, N(O)m═CR6—CR7═CR8, CR5═CR6—N(O)m═CR8, CR5═CR6—CR7═N(O)m, CR5═CR6—O, CR5═CR6—S, O—CR7═CR8, S—CR7═CR8 or O—CR7═N;Y represents 13 CH2S—, —CH2SO—, —CH2SO2—, —CH2O—, —CH═CH—, —(CH2)p—, —SCH2—, —SOCH2—, —SO2CH2— or —OCH2—; andR2 represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkoxy, amino, mono(substituted or unsubstituted lower alkyl)-substituted amino, di(substituted or unsubstituted lower alkyl)-substituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkylamino, substituted or unsubstituted arylamino or a substituted or unsubstituted heteroalicyclic group] or a pharmaceutically acceptable salt thereof.