Death domain containing receptors
US7357927B2 · kind B2 · utility
8Cited by
8References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 5, 2002 |
| Grant date | Apr 15, 2008 |
| Priority date | — |
| Expiry date | Feb 24, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/026
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.