Bone graft material incorporating demineralized bone matrix and lipids
US7357947B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Apr 11, 2003 |
| Grant date | Apr 15, 2008 |
| Priority date | — |
| Expiry date | Oct 20, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K35/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
One embodiment of the invention is demineralized bone putty composition comprises: (1) demineralized bone matrix (DBM); and (2) a lipid fraction selected from the group consisting of lecithin and a mixture of lecithin and triglycerides containing unsaturated fatty acids. The putty composition is moldable, biocompatible, slowly resorbable, insoluble in tissue fluids, and non-extrudable. The composition delivers a biologically active product to animals and humans that will enhance bone formation at sites where bone is lost, deficient, or present in suboptimal amounts. The composition can further comprise calcium, an antioxidant such as Vitamin E or Vitamin C, or a hydrophilic polymer such as methylcellulose, a methylcellulose derivative, carboxymethyl cellulose, or hydroxypropyl methylcellulose. A second embodiment of the invention is a demineralized bone paste composition comprising: (1) about 15% to about 75% of an emulsion carrier, such as an aqueous phase; and (2) a bone-material-containing phase comprising: (a) demineralized bone matrix (DBM); and (b) an emulsifier component that is compatible with lipids. This bone paste composition is moldable, biocompatible, slowly resorbable…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.