Enhanced secretion of a polypeptide by a microorganism
US7358084B2 · kind B2 · utility
20Cited by
3References
3Claims
0Family size
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Key dates
| Filing date | Aug 26, 2004 |
| Grant date | Apr 15, 2008 |
| Priority date | — |
| Expiry date | Aug 26, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/95
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described herein are methods for the enhanced production of secreted proteins. The secretion of a protein of interest having a substantially non-polar carboxy tail is enhanced by the placement of charged amino acid residues at the carboxy terminus either by adding to the native peptide or by replacing, i.e., substituting, the terminal residues of the native peptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.