Device for capturing beads and method and apparatus for arraying beads
US7358098B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 3, 2005 |
| Grant date | Apr 15, 2008 |
| Priority date | — |
| Expiry date | Mar 29, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2035/00574
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Beads having diameters of several tens of micrometers to several millimeters and immobilized with biomolecules are captured by one kind of bead capturing nozzle one by one without fail. Using a bead holding plate having a plurality of wells each of which holds a plurality of the beads and a solution, a vibration generator mounted with a stage to attach the bead holding plate, and a bead capturing nozzle for bead capture connected to a suction pump, only a single bead is captured at the tip of the bead capturing nozzle by inserting the nozzle having an inner diameter smaller than the beads and a negative pressure inside created by the pump into the solution to allow the nozzle to come in contact with the beads in the well, applying a vibration to the bead holding plate by the vibration generator, and withdrawing the bead capturing nozzle into the air.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.