Imidazole derivatives as factor Xa inhibitors

US7358268B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Marc Nazare · Idstein, DE
• Armin Bauer · Pocking, DE
• Volkmar Wehner · Bischofsheim a.d.Rhön, DE
• David William Will · Schwalbach, DE
• Hans Matter · Langenselbold, DE
• Michael Wagner · Frankfurt am Main, DE
• Herman Schreuder · Frankfurt am Main, DE

Key dates

• Filing date: Dec 4, 2003
• Grant date: Apr 15, 2008
• Expiry date: Sep 29, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention is directed to the compound of formula (I) which is useful for inhibiting the activity of Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their use, such as in inhibiting the formation of thrombin or for therapeutically or prophylactically treating a patient suffering from, or subject to, or associated with a disease state associated with a cardiovascular disorder.