Internal 1,15-lactones of fluprostenol and related prostaglandin F2a analogs and their use in the treatment of glaucoma and intraocular hypertension
US7358275B2 · kind B2 · utility
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3Claims
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Key dates
| Filing date | Feb 14, 2006 |
| Grant date | Apr 15, 2008 |
| Priority date | — |
| Expiry date | Apr 22, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D327/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel derivatives of prostaglandin compounds of the F-series (PGF), specifically macrocyclic internal 1,15-lactones of fluprostenol and related PGF analogs, such as cloprostenol or latanoprost. The novel analogs can be formulated into ophthalmic solutions and topically applied for the treatment of the increased intraocular pressure caused by glaucoma and the reduction of ocular hypertension.
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