Nucleic acids encoding human TNF-α convertase
US7358352B2 · kind B2 · utility
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11References
6Claims
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Key dates
| Filing date | Nov 13, 2006 |
| Grant date | Apr 15, 2008 |
| Priority date | — |
| Expiry date | Nov 13, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96486
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and; recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the convertases and are useful for treating medical conditions caused or mediated by TNF-α. Also provided are screening methods for identifying specific inhibitors of mammalian TNF-α convertases, and for identifying nucleic acids encoding such convertases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.