Patent · US Expired

Influenza immunogen and vaccine

US7361352B2 · kind B2 · utility

44Cited by

21References

45Claims

0Family size

Assignees

Acambis Inc. · US
VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW · BE

Inventors

Ashley Birkett · Escondido, US
Walter Fiers · Laarne, BE

Key dates

Filing date	Feb 26, 2004
Grant date	Apr 22, 2008
Priority date	—
Expiry date	Feb 26, 2024

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An immunogenic influenza sequence in two to four copies is preferably expressed at or near the N-terminus or in the HBc immunogenic loop sequence. The HBc chimer preferably contains an influenza-specific T cell epitope and is preferably engineered for both enhanced stability of self-assembled particles and enhanced yield of those chimeric particles. Methods of making and using the chimers are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.