Methods for treating malignancies expressing ICAM-1 using coxsackie a group viruses
US7361354B1 · kind B1 · utility
2Cited by
13References
22Claims
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Key dates
| Filing date | Nov 27, 2000 |
| Grant date | Apr 22, 2008 |
| Priority date | — |
| Expiry date | Apr 12, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/32371
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognizing at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.