Diagnosis of lysosomal storage disorders using saposins and other markers
US7361481B2 · kind B2 · utility
3Cited by
6References
5Claims
0Family size
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Key dates
| Filing date | Oct 26, 2004 |
| Grant date | Apr 22, 2008 |
| Priority date | — |
| Expiry date | Mar 16, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/924
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods for assaying a lysosomal enzyme activity present in a blood sample obtained from a patient. The method combines the blood or plasma sample in a buffer with at least one binding reagent capable of reacting with alpha-glucosidase present in the blood sample to form an enzyme reagent complex. The lysosomal enzyme activity present in the blood sample is then determined from the enzyme reagent complex formed and compared to a mean level of alpha-glucosidase in a control population of individuals not having a lysosomal storage disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.