Process for the production of atorvastatin calcium

US7361772B2 · kind B2 · utility

Assignee

• Biocon Ltd. · IN

Inventors

• Joy Mathew · Savanuru, IN
• Madhavan Sridharan · Savanuru, IN
• Sambasivam Ganesh · Savanuru, IN
• Tom Thomas Puthiaparampil · Kottayam, IN

Key dates

• Filing date: Oct 7, 2003
• Grant date: Apr 22, 2008
• Expiry date: Dec 20, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

In one aspect, the invention provides a process for the production of 5-(4-Fluoro-phenyl)-2-isopropyl-4-phenyl-1-(3,5,7-trihydroxy-heptyl)-1H-pyrrole-3-carboxylic acid phenylamide hemicalcium salt, stereoisomers thereof or polymorphs thereof from a (6-{2-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrolidin-1-yl]-ethyl}-2-phenyl-[1,3,2]dioxaborinan-4-yl)-acetic acid tert-butyl ester.