(2S)-2-ethylphenylpropionic acid derivative
US7361783B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 26, 2003 |
| Grant date | Apr 22, 2008 |
| Priority date | — |
| Expiry date | May 26, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D263/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides novel (2S)-2-ethylphenylpropanoic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor (PPAR) α to activate and exhibit lipid-lowering effect, inhibitory effect on the arteriosclerosis, antiobesity effect, blood glucose-lowering effect, etc., their addition salts, and their medicinal compositions.(2S)-2-Ethylphenylpropanoic acid derivatives represented by a general formula (1)[wherein R1 denotes a halogen atom or trifluoromethyl group, R2 denotes a hydrogen atom, halogen atom or trifluoromethyl group, and, when R2 denotes a hydrogen atom, R3 denotes a halogen atom or trifluoromethyl group and, when R2 denotes a halogen atom or trifluoromethyl group, R3 denotes a hydrogen atom, halogen atom or trifluoromethyl group], and their addition salts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.