Nucleic acid participating in the formation of presenilin-2-gene exon 5-defective splicing variant
US7364847B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Jun 27, 2002 |
| Grant date | Apr 29, 2008 |
| Priority date | — |
| Expiry date | Feb 3, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a means for treatment and/or prevention of a disease caused by aberrant splicing, a neurodegenerative disease represented by Alzheimer's disease, or the like. The present invention relates to a nucleic acid which can be associated with generation of a splice variant that lacks exon 5 of presenilin-2 gene, an inhibitor for inhibiting a binding between protein-nucleic acid caused by aberrant splicing, and a method for screening the inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.