Antibodies to myeloid progenitor inhibitory factor-1 (MPIF-1)

US7364865B2 · kind B2 · utility

Assignee

• HUMAN GENOME SCIENCES, INC. · US

Inventors

• Reiner Gentz · Silver Spring, US
• Brent L. Kreider · Bedford, US
• Jun Zhang · Xiamen, CN
• Michael Antonaccio · Princeton, US
• Donna Mendrick · Mount Airy, US
• Pablo Jimenez · Ellicott City, US
• Vikram Patel · Germantown, US
• Craig Rosen · Laytonsville, US
• Mark D. Adams · Potomac, US
• Haodong Li · Gaithersburg, US
• Steven Ruben · Olney, US

Key dates

• Filing date: May 5, 2006
• Grant date: Apr 29, 2008
• Expiry date: May 5, 2026

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1(CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.