Compounds with improved cartilage-inducing and/or bone-inducing activity

US7365051B2 · kind B2 · utility

Assignee

• Biopharm Gesellschaft Zur Biotechnologischen Entwicklung von Pharmaka MBH · DE

Inventors

• Michael Paulista · Leimen, DE
• Jens Pohl · Bad Schönborn, DE
• Joachim Pabst · Reinheim, DE
• Helmut Heide · Kelkheim, DE

Key dates

• Filing date: Mar 16, 2005
• Grant date: Apr 29, 2008
• Expiry date: Mar 16, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/51
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention concerns a bioactive implant material having a cartilage-inducing and/or bone-inducing activity composed of two components A and B, of which A is a bone-inducing and/or cartilage-inducing protein or protein mixture and preferably one or several proteins from the TGF-β superfamily, preferably MP52 or a DNA sequence coding therefor and B is a carrier matrix composed of calcium phosphate ceramics with an interconnecting microporosity which already alone has bone-inducing properties. The invention additionally concerns the production of these compounds and their use for the treatment of diseases which affect cartilage and/or bones as well as to treat damage to cartilage and/or bone tissue.