Peptides antagonistic to an anti-angiogenic antibody and uses therefor
US7365154B2 · kind B2 · utility
1Cited by
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3Claims
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Key dates
| Filing date | Jun 22, 2004 |
| Grant date | Apr 29, 2008 |
| Priority date | — |
| Expiry date | Aug 2, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/70557
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention concerns antagonists of alphav-containing integrins which have therapeutic activity in oncology applications and methods for selecting such antagonists using a peptide which competes for alphaV-integrin binding with a known monoclonal antibody having demonstrated anti-tumor activity. The claimed peptide represents a conformational epitope or mimotope present on the ligand to which the therapeutic antibodies selectively bind.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.