Acyl-nucleotide probes and methods of their synthesis and use in proteomic analysis
US7365178B2 · kind B2 · utility
4Cited by
8References
28Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 1, 2004 |
| Grant date | Apr 29, 2008 |
| Priority date | — |
| Expiry date | Jul 8, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/485
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides tagged acyl phosphate probes (“TAPPs”), and methods of their preparation and use. The subject methods and compositions can provide enhanced simplicity and accuracy in identifying changes in the presence, amount, or activity of target proteins in a complex protein mixture, preferably nucleotide binding proteins using nucleotide binding protein-directed TAPPs. The profiling methods described herein can have a number of steps leading to the identification of target nucleotide binding protein(s) in a complex protein mixture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.