Nitrogen heterocycle biaryls for osteoporosis and other diseases

US7365209B2 · kind B2 · utility

Assignee

• PHARMACOPEIA, LLC · US

Inventors

• Jeffrey J. Letourneau · Plainsboro, US
• Vidyahar Paradkar · Somerville, US
• Michael H. J. Ohlmeyer · Plainsboro, US
• Lawrence W. Dillard · Hopewell, US
• John J. Baldwin · Gwynedd Valley, US
• Christopher Riviello · Old Forge, US
• Angela Wong · North Wales, US
• Yaing Rong · Monmouth Junction, US

Key dates

• Filing date: Feb 10, 2004
• Grant date: Apr 29, 2008
• Expiry date: Jun 28, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Nitrogen heterocycle biaryls having a carboxylate terminus are useful for treating endometriosis, osteoporosis, restenosis following angioplasty, rheumatoid arthritis, cancer, macular degeneration and obesity.Compounds of formula:are disclosed. A representative example is