Process for preparing guggulsterones
US7365218B2 · kind B2 · utility
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Key dates
| Filing date | Mar 20, 2003 |
| Grant date | Apr 29, 2008 |
| Priority date | — |
| Expiry date | Jan 24, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/0052
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides an improved process for the preparation of Guggulsterones which comprises epoxidising 16-dihydropegnenolone acetate (16 DPA) by reacting 16DPA with hydrogen peroxide reagent adduct in the presence of a co-base in a polar solvent to obtain 3 β hydroxy-16 α, 17-oxido-5 pregnen-20-one, converting the 3 β hydroxy-16α, 17-oxido-5-pregnen-20-one by reacting with hydrazine in the presence of a strong base at refluxing temperature followed by oxidation to obtain desired guggulsterones viz. to 5, 17-(20)-cis and trans pregnadiene-3 β, 16-diol of the formula Ia and Ib.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.