Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (PACAP)
US7368115B2 · kind B2 · utility
13Cited by
48References
42Claims
0Family size
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Key dates
| Filing date | Jul 31, 2003 |
| Grant date | May 6, 2008 |
| Priority date | — |
| Expiry date | Oct 1, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/35
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a method of increasing the number and/or differentiation of neural stem cells and/or neural stem cell progeny using pituitary adenylate cyclase-activating polypetide (PACAP). In a preferred embodiment, additional growth factors are also utilized. The present invention can be practiced in vivo and in vitro, rendering it useful for the treatment of neurodegenerative disease and other neural trauma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.