Controlled release depot formulations

US7368126B2 · kind B2 · utility

Inventors

• Guohua Chen · Sunnyvale, US
• Paul R. Houston · Hayward, US
• Roy Bannister · Hollister, US
• Teresa Kameda · Sunnyvale, US
• David Priebe · Bellevue, US
• Lothar W. Kleiner · Los Altos, US

Key dates

• Filing date: Nov 4, 2003
• Grant date: May 6, 2008
• Expiry date: Jun 19, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/204
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and compositions for systemically or locally administering a beneficialagent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.