Radiofluorination methods

US7368474B2 · kind B2 · utility

Assignee

• GE HEALTHCARE LIMITED · GB

Inventors

• Alan Cuthbertson · San Jose, US
• Magne Solbakken · Oslo, NO
• Joseph Maduabuchi Arukwe · Oslo, NO
• Hege Karlsen · Oslo, NO

Key dates

• Filing date: Mar 20, 2003
• Grant date: May 6, 2008
• Expiry date: May 6, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B59/008
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to methods and reagents for [18F]-fluorination, particularly of peptides. The resultant 18F-labelled compounds are useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET). Thus, a compound of formula 18F-(Linker)-SH, such as a compound of formula (IV), (V), or (VI):18F—(CH2CH2O)n—(CH2)m—SH   (IV)18F—(CH2)p—SH   (V)may be reacted with an activated peptide as a means for 18F-labelling.