Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of prostate cancer

US7368548B2 · kind B2 · utility

Assignee

• Compugen Ltd. · IL

Inventors

• Dvir Dahary · Nes Ziona, IL
• Sarah Pollock · Nes Ziona, IL
• Zurit Levine · Herzliya, IL
• Rotem Sorek · Rehovot, IL
• Michal Ayalon-Soffer · Ramat HaSharon, IL
• Pinchas Akiva · Ramat Gan, IL
• Amir Toporik · Holon, IL
• Osnat Sella-Tavor · Ein Mahel, IL
• Shirley Sameah-Greenwald · Kfar Sava, IL

Key dates

• Filing date: Jan 27, 2005
• Grant date: May 6, 2008
• Expiry date: May 27, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Novel markers for prostate cancer that are both sensitive and accurate. Furthermore, these markers are able to distinguish between prostate cancer and benign prostate hyperplasia (“BPH”). These markers are overexpressed in prostate cancer specifically, as opposed to normal prostate tissue and/or BPH. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of prostate cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between prostate cancer and non-cancerous states.