Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
US7368565B2 · kind B2 · utility
133Cited by
7References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 5, 2002 |
| Grant date | May 6, 2008 |
| Priority date | — |
| Expiry date | Aug 29, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses a one-step process for the production of cytotoxic conjugates of maytansinoids and cell binding agents. Maytansinoids having a disulfide linker that bears a reactive moiety are linked to cell binding agents, such as antibodies, without prior modification of the cell binding agent. These conjugates are useful as therapeutic agents which are delivered specifically to target cells and are cytotoxic.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.