Methods of inhibiting αvβ3-mediated binding with αvβ3-specific antibodies
US7371382B2 · kind B2 · utility
8Cited by
11References
56Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 25, 2002 |
| Grant date | May 13, 2008 |
| Priority date | — |
| Expiry date | Aug 20, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/565
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides enhanced LM609 grafted antibodies exhibiting selective binding affinity to αVβ3, or a functional fragment thereof. The invention also provides nucleic acid molecules encoding the enhanced LM609 grafted antibodies. Additionally provided are methods of inhibiting a function of αVβ3 by contacting αVβ3 with an enhanced LM609 grafted antibody.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.