Serial derivatization of peptides for de novo sequencing using tandem mass spectrometry
US7371514B2 · kind B2 · utility
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11Claims
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Key dates
| Filing date | Jul 16, 2004 |
| Grant date | May 13, 2008 |
| Priority date | — |
| Expiry date | Sep 14, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6848
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Serial derivatization by chemical reactions of analytes for mass spectrometry is disclosed. The derivatizations enhance the use of MS techniques for analyzing protein samples, particularly when the sequence of a polypeptide is determined by tandem MS/MS. Accurate mass analysis techniques are described for use in sequencing polypeptides, together with the use of sequencing data in protein analysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.