Patent · US Expired

Prostate-specific antigen probes for optical imaging

US7371728B2 · kind B2 · utility

1Cited by
0References
3Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJan 4, 2006
Grant dateMay 13, 2008
Priority date—
Expiry dateJan 4, 2026

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2319/00
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

This invention provides a novel probe, which contains a prostate peptide substrate. The probe can be used as a prostate diagnostic agent for optical imaging. An 11 amino acid peptide substrate is synthesized for specific prostate-specific antigen (PSA). This protected graft copolymer (PGC) consists of a poly-L-lysine (PL) backbone and methoxypoly(ethylene glycol) (MPEG). Two terminals of peptide substrate are bound to poly-L-lysine and Cy5.5 fluorochrome. This probe will be used as a NIR (near-infrared fluorescence) probe for optical imaging.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.