Preparation of aromatic and heteroaromatic carboxylic acids by catalytic ozonolysis
US7371866B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 15, 2003 |
| Grant date | May 13, 2008 |
| Priority date | — |
| Expiry date | Jun 26, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for catalytically oxidizing alkylaromatic compounds of the formula (I)Ar—CH2—Rwhere Ar is an optionally substituted, aromatic or heteroaromatic 5-membered or 6-membered ring or a ring system having up to 20 carbon atoms where Ar may optionally be fused to a C1-C6-alkyl group in which up to 2 carbon atoms may be replaced by a heteroatom, and R is hydrogen, phenyl, benzyl or heteroaryl, where the phenyl, benzyl or heteroaryl radicals may also be joined to Ar by a bridge, or R together with Ar forms an optionally substituted ring system which may contain one or more optionally substituted heteroatoms, to the corresponding aromatic or heteroaromatic carboxylic acids in a solvent with ozone in the presence of a transition metal catalyst and optionally in the presence of an acid at a temperature between −70° C. and 110° C. to the corresponding carboxylic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.