Non-racemic trifluoroleucine, and methods of making and using
US7371867B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 6, 2006 |
| Grant date | May 13, 2008 |
| Priority date | — |
| Expiry date | Nov 6, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/06191
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides comprising hexafluoroleucine and congeners thereof have been characterized using comparative biophysical studies. In general, the fluorinated peptides show higher thermal stability and enhanced resistance to chemical denaturation. Further, mixed hydrocarbon-fluorocarbon cores self-sort into homogeneous bundles, suggesting new avenues for the design and manipulation of protein-protein interfaces.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.