Amino substituted hydroxyphenyl benzophenone derivatives

US7374749B2 · kind B2 · utility

Assignee

• Ciba Specialty Chemicals Corporation · US

Inventors

• Jürg Haase · Bettingen, CH
• Thomas Ehlis · Glückstadt, DE
• Elek Borsos · Birsfelden, CH
• Stefan Muller · Weil am Rhein, DE

Key dates

• Filing date: Dec 3, 2003
• Grant date: May 20, 2008
• Expiry date: Mar 6, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D313/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R1, and R2 independently from each other are; C1-C20alkyl; C2-C20-alkenyl; C3-C10cycloalkyl; C3-C10cycloalkenyl; or R1, and R2 together with the linking nitrogen atom form a 5- or 6-membered heterocyclic ring; n1 is a number from 1 to 4; when n1=1, R3 is a saturated or unsaturated heterocyclic radical; hydroxy-C1-C5alkyl; cyclohexyl optionally substituted with one or more C1-C5alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C1-C5alkylcarboxy; when n1 is 2, R3 is an alkylene-, cycloalkylene- or alkenylene radical which is optionally substituted by a carbonyl- or carboxy group; o R3 together with A forms a bivalent radical of the formula (Ia), wherein n2 is a number from 1 to 3; when n1 is 3, R3 is an alkanetriyl radical; when n1 is 4, R3 is an alkanetetrayl radical; A is —O—; or —N(R5)—; and R5 is hydrogen; C1-C5alkyl; or hydroxy-C1-C5alkyl. The compounds are useful as UV filters in sunscreen applications.