Topical composition for follicular delivery of an ornithine decarboxylase inhibitor
US7374770B2 · kind B2 · utility
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13References
26Claims
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Key dates
| Filing date | Aug 13, 2002 |
| Grant date | May 20, 2008 |
| Priority date | — |
| Expiry date | Jul 4, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/782
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polyethylene glycol ethers of alkyl alcohols having the general formula CH3(CH2)xCH2(OCH2CH2)nOH wherein x is 8 to 20 (of which ceteareth-20, steareth-20 and steareth-100 are preferred), poloxamer 185, poloxamer 407, N,N-dimethyl dodecylamine N-oxide, and mixtures thereof, are employed to increase follicular delivery and/or follicular residence time of certain water soluble ornithine decarboxylase inhibitors of which 2(difluoromethyl)-2,5-diamino pentanoic acid and its pharmaceutically acceptable salts, hydrates, optical enantiomers and racemic mixture are preferred.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.