Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US7374779B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 11, 2002 |
| Grant date | May 20, 2008 |
| Priority date | — |
| Expiry date | Nov 19, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5084
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention pertains to pharmaceutical formulations and systems for delivery of active agents, wherein a first fraction of an active agent is suspended in a vehicle and a second fraction of active agent is solubilized in the vehicle, with the suspended fraction representing about 5 wt. % to about 80 wt. % of the active agent and the second fraction representing about 20 wt. % to about 95 wt. % of the active agent. One or more additional active agents, which may be fully solubilized, partially solubilized, or suspended, may also be present. The first and second fractions of the active agent may or may not have different release profiles. Generally, a significant fraction of the solubilized drug will release rapidly, providing for rapid onset, while the suspended drug may be formulated for delayed and/or sustained release.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.